In vitro Evaluation of Carvacrol and Colistin Combination Against Colistin Resistant Acinetobacter baumanni Strains
نویسندگان
چکیده
منابع مشابه
In vitro synergism of combinations of colistin with selected antibiotics against colistin-resistant Acinetobacter baumannii
AIM The in vitro activity of colistin in combination with sulbactam, netilmicin, and vancomycin against colistin-resistant A. baumannii strains was investigated. Furthermore, the clonal relationship of the strains was analyzed. METHODS Clonal relationship was investigated using rep-PCR. To screen for synergysm, the fractional inhibitory concentration index (FICI) was calculated using checkerb...
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32 In two pairs of clinical colistin-susceptible/colistin-resistant (ColS/ColR) Acinetobacter 33 baumannii, ColR strains showed significantly decreased biofilm formation in static and dynamic 34 assays (P<0.001) and lower relative fitness (P<0.05) compared with ColS. Whole genome 35 sequencing comparison of strain pairs identified in one ColR strain a *241K change in LpsB 36 (involved in LPS sy...
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We present the case of a patient with ventilator-associated pneumonia (VAP) caused by a pan-resistant Acinetobacter baumannii successfully treated with the combination colistin plus vancomycin plus rifampin, whose in vitro activity was investigated by checkerboard method and killing testing. Furthermore, the serum bactericidal activity (SBA) was assessed. Our case shows that an innovative regim...
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OBJECTIVES Antimicrobial treatment of multidrug-resistant Acinetobacter baumannii (MDRAB) remains an important therapeutic challenge. With isolates resistant to all conventional agents now reported, clinicians are increasingly forced to turn to unorthodox combination treatments in the hope that these may be efficacious. Although a potent interaction between vancomycin and colistin has been demo...
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Treatment of infections due to extensively drug-resistant (XDR) Acinetobacter baumannii often involves the use of antimicrobial agents in combination. Various combinations of agents have been proposed, with colistin serving as the backbone in many of them. Recent data suggest that glycopeptides, in particular vancomycin, may have unique activity against laboratory-adapted and clinical strains o...
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ژورنال
عنوان ژورنال: Türk Mikrobiyoloji Cemiyeti Dergisi
سال: 2019
ISSN: 0258-2171
DOI: 10.5222/tmcd.2019.067